Posters

Topological localization of C-reactive protein determines its effect on barrier disruption in retinal pigment epithelial cells.

Sara Romero Vázquez

Sara Romero-Vázquez, Alfredo Adan, Blanca Molins. PURPOSE. The retinal pigment epithelium (RPE) of the outer blood retinal barrier (oBRB) is the prime target in age-related macular degeneration (AMD). C-reactive protein (CRP) is an acute phase reactant and a serum biomarker of chronic inflammation. It presents two isoforms with distinct biological functionalities: the pentameric (pCRP) and the monomeric (mCRP) form, being …

Identidad reflexiva docente de profesores en formación desde la Teoría del Self Dialógico

Brenda Lara

Durante la formación inicial y en el ejercicio de la profesión docente se reconoce que existen dificultades para que los profesores den razones fundamentadas de las decisiones que toman. En el ámbito educativo con frecuencia los argumentos se sustentan en creencias o experiencias. Este fenómeno limita las posibilidades de comprensión, análisis e intervención, tanto desde la perspectiva de su desarrollo …

Placing favelas on the tourist city map: Between commodification and representation

Eugenia Altamirano

This research aims to analyse the role of tourism practices and performances as a socio-economic activity and its capacity, real and potential, to re-signify and transform the physical, social and cultural landscape of urban tourist destinations. The case study focuses on informal urban settlements of Rio de Janeiro, locally known as favelas, which carry almost 30 years of polemic tourist development. …

Differential expression of exosomal miRNAs in familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) patients

Mònica Vall Palomar

Familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) is a rare autosomal recessive disorder caused by mutations in CLDN16 or CLDN19 genes. This disease is characterized by massive urinary wasting of magnesium and calcium, nephrocalcinosis and inexorable progression to chronic kidney disease which leads to renal replacement therapy and kidney transplantation. Patients homozygous for p.G20D mutation in CLDN19 gene, the most …

Establishment of cell models of Dent’s disease for the discovery of molecular targets and therapeutic solutions.

Mónica Durán

Dent’s Disease (DD) is a rare X-linked condition affecting proximal renal tubules caused by mutations in the CLCN5 gene that encodes for the CLC-5 exchange transporter. Clinically, it is characterized by low molecular weight proteinuria, which is a hallmark of the renal Fanconi’s syndrome, hipercalciuria, nephrocalcinosis and progression to end-stage-renal-failure. Currently, there are no treatments or ongoing clinical trials for …

Communication towards social eco change, activism and post-development: alternative press as a political strategy in ecological conflicts by extractivism in Ecuador

Yadis Vanegas

Este proyecto de investigación surge a partir de la problemática socio-ambiental provocada por la política extractivista del Estado ecuatoriano, en el marco de las luchas comunicacionales, interculturales y ecológicas. La constitución del Ecuador vigente (2008) reconoce como horizonte al <Buen Vivir> que, desde los principios de pluriculturalidad e interculturalidad, reivindica los derechos colectivos, derechos de autoderminación y derechos de la …

CM-728 as a novel and potential new compound for metastatic ccRCC treatment.

Jazmine Arévalo

Clear cell renal cell carcinoma (ccRCC) is the most prevalent and lethal histological subtype of renal cell carcinoma (RCC) because of its asymptomatic phenotype associated with chemotherapy and radiotherapy resistance. If ccRCC is detected at early stages, partial or radical nephrectomy is the first-line treatment increasing survival in 65% of patients. Conversely, if detection occurs in advanced metastatic stage, drugs …

The role of allosteric networks in GPCR signalling bias

Adrian Morales Pastor

G-protein coupled receptors (GPCRs) are important drug targets as they are involved in almost every physiological process. When a drug binds to a GPCR, it stabilizes conformational states which are characterized by the engagement of distinct allosteric networks[1]. Specific receptor states allow the GPCR to interact with intracellular transducers which trigger selected signalling cascades in the cell. Typically, a GPCR …

The use of empowerment strategy to achieve Total Quality Management in civil associations

Marwa Gomaa Abdelghani Bassiouni

Background. Civil associations suffer from poor performance due to several reasons, including the lack of planning, teamwork, focus on customers, the neglect of staff training, as well as the lack of effective leadership within these associations. The Total Quality Management (TQM) is an effective approach that focuses to improve the associations’ outputs, including services, and performance which will meet or exceed …

Item Response Theory analysis of the Wechsler Adult Intelligence-Fourth Edition

Gomaa Said Mohamed Abdelhamid

Background. The Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV) is essential to a wide range of practitioners for assessing adult intelligence (Weiss, Saklofske, Coalson, & Raiford, 2010). The WAIS-IV composes of 15 subtests (10 core and 5 supplemental) assessing the efficacy of cognitive ability in four domains (Verbal Comprehension, Perceptual Reasoning, Working Memory and Processing Speed). Abdelhamid, Gómez-Benito, Abdeltawwab, Abu Bakr …