Sham hemodialysis. From basics to clinical practice.

2017 edition

Miquel Gomez Umbert

Hemodialysis consists in a blood extracorporeal treatment for end stage renal disease patients. In brief, the continuously extracted blood from the patient is submitted to a diffusion/convection process through a semi-permeable membrane (dialyzer), surrounded by a biocompatible bath. Thus, toxins are eliminated from the body whereas the electrolytic balance is maintained.

In order to improve the outcomes in the clinical practice, it is of paramount importance the assessment of the viability of new developed materials and routines in the pre-clinical stages. Furthermore, the fast-improving dialysis technology needs constant up-dated information of the blood-dialyzer interaction.

Sham (fake or simulated) hemodialysis allows the performance a variety of preclinical studies involving, for instance, the development of new medicines; analyze the behavior of the already used ones in the extracorporeal circuit or the study of new membrane materials.

In addition to the simulated ex vivo hemodialysis, computer modeling as well as patient uremic toxin level measurement leads to an overall characterization and a deep understanding of the dialysis treatment.